Tissue Lysates
Cayman Chemical SynthetIc CIrsIlIol 1mg
A flavonoid with diverse biological activities; inhibits 5-LO and 12-LO (IC50s = 0.1 and 1 µM, respectively); inhibits release of SRS-A in passively sensitized isolated guinea pig lung (IC50 = 0.4 µM); induces relaxation of isolated precontracted rat uterus, urinary bladder, proximal aorta, and trachea; inhibits colony formation and migration of B16/F10 murine melanoma cells; enhances radiation-induced inhibition of tumor growth in an H1299 NSCLC mouse xenograft model at 200 UG/kg
Cayman Chemical TRIM33 PHD nd bromodomaInh 1mg
Source: Recombinant N-terminal GST-tagged protein expressed in E. coli • MW: 51.4 kDa
Cayman Chemical GLP-2ratrIfluoroacetate 1mg
A gut peptide hormone agonist of GLP-2R; increases cAMP levels in COS cells expressing GLP-2R (EC50 = 0.58 nM); produced by enteroendocrine L cells of the small and large intestine and in the hypothalamus; increases small bowel weight by 50% and increases villus height and crypt cell proliferation in the small intestine of mice (43.75 μg twice per day for 10 days); reduces two-hour food intake in rats by 37% (10 μg); secretion is stimulated by dietary carbohydrates, glucose, dextrin, and oils rich in polyunsaturated or monounsaturated fatty acids
Cayman Chemical MDMB-CHMICA metabolIte M2 1mg
An analytical reference standard categorized as a synthetic cannabinoid metabolite; a metabolite of MDMB-CHMICA; intended for research and forensic applications
Cayman Chemical RCS4 N 5hydroxypentyl met 1mg
An internal standard for the quantification of RCS-4 N-(5-hydroxypentyl) metabolite by GC- or LC-MS; intended for research and forensic applications.
Cayman Chemical SynthetIc DIctamnIn 1mg
An alkaloid with diverse biological activities; inhibits arachidonic acid-, collagen-, thrombin-, or PAF-induced platelet aggregation in washed isolated rabbit platelets at 100 UG/ml; cytotoxic to human KB oral, HeLa cervical, and DLD-1 colon cancer cells (EC50s = 20.55, 2.5, and 6.4 UG/ml, respectively) and induces apoptosis in A549, PC-9, and EBC-1 human lung cancer cells from 50-200 µM; increases serum ALT and ALP activities and induces hepatocyte necrosis in mice at 150 or 200 mg/kg
Bio Rad Laboratories BiSpyCatcher2, Recombinant Protein, 1mg
BiSpyCatcher2 (H-BiSpyC2) is a 29 kDa homodimer of SpyCatcher2 (TZC001) bridged with a flexible linker. Each SpyCatcher2 subunit can form a stable covalent isopeptide bond with a second protein that includes a SpyTag. The reaction occurs spontaneously on mixing, is rapid, irreversible, high-yielding and shows good specificity. BiSpyCatcher2 contains a His6-tag at the N-terminus. To avoid deamidation of asparagine, a N105D mutation was introduced (Hentrich et al. 2020) for each of the two Catchers.The reaction is robust at pH 5 to 8, at temperatures from +4°C to +37°C, in various buffer conditions (Ca2+/Mg2+ not needed) and in the presence of detergents. The reaction also occurs inside cells (in vivo). Since the speed of the coupling reaction is concentration dependent, it is recommended to use BiSpyCatcher2 undiluted.All the different formats of BiSpyCatcher2 are compatible with Bio-Rad's recombinant HuCAL® antibodies with a SpyTag2
Cayman Chemical 1 3-DIeIcosenoyl Glycerol 1mg
A diacylglyerol containing 11(Z)-eicosenoic acid at the sn-1 and sn-3
Cayman Chemical C24 1 3sulfo GalactosylcRa 1mg
A sulfatide; interacts with LMIR5 to increase activation of NFAT; an immunodominant species that is bound by CD1d in vitro; reduces symptoms, increases survival, and decreases inflammatory lesions in a mouse model of chronic relapsing-remitting EAE (20 UG)
Cayman Chemical SynthetIc Obovatol 1mg
A lignan polyphenol with diverse biological activities; inhibits epinephrine- or arachidonate-induced aggregation of isolated rat platelets (IC50s = 59 and 54 µM, respectively); induces cell cycle arrest at the S phase and apoptosis in SW620 cancer cells at 50 µM; reduces tumor volume and weight in a SW620 mouse xenograft model at 6 mg/kg per day; decreases hippocampal and cortical Aβ42 fibril formation and reduces latency and distance to escape in the Morris water maze in a Tg2576 mouse model of Alzheimer's disease at 1 mg/kg per day for three months
Cayman Chemical BB22 7hydroxyIsoquInolIn I 1mg
BB-22 7-hydroxyisoquinoline isomer differs from BB-22 structurally by having the quinoline group replaced with an isoquinoline group attached at its seven position; intended for forensic and research applications
Cayman Chemical AltertoxIn I 1mg
A natural mycotoxin that shows mutagenic activity against S. typhimurium and inhibits human topoisomerase II and bacterial gyrase; completely inhibits replication of HIV-1 virus at 2.2 µM in a cell-based assay